| 型號(hào)： | 分析純、工業(yè)級(jí)、各種級(jí)別 |
| 規(guī)格： | 更多規(guī)格請(qǐng)聯(lián)系客服 |
| 特色： | 出口、危包、商檢、全國(guó)送貨 |
| 單價(jià)： | 面議 |
| 發(fā)貨期限： | 自買(mǎi)家付款之日起 天內(nèi)發(fā)貨 |
| 所在地： | 廣東 廣州 |
| 有效期至： | 長(zhǎng)期有效 |
| 發(fā)布時(shí)間： | 2025-04-13 03:23 |
| 最后更新： | 2025-04-13 03:23 |
| 瀏覽次數(shù)： | 61 |
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| CAS | |
| EINECS | |
| 化學(xué)式 | C17H19ClN2S |
| 分子量 | 318.86 |
| InChI | InChI=1/C17H19N2S.ClH/c6(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1 |
| 密度 | 1.301g/cm3 at 20℃ |
| 熔點(diǎn) | 211-212 °C (decomp) |
| 蒸汽壓 | 0Pa at 25℃ |
| 溶解度 | 甲醇: 可溶物1mg/mL |
| 存儲(chǔ)條件 | Store below +30°C. |
| 外觀 | 粉末 |
| 顏色 | Yellow to ochre-yellow |
| BRN | 3922452 |
| MDL號(hào) | MFCD00011944 |
| 體外研究 | Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission. |
| 安全術(shù)語(yǔ) | 24/25 - 避免與皮膚和眼睛接觸。 |
| 危險(xiǎn)品運(yùn)輸編號(hào) | 2811 |
| WGK Germany | 3 |
| TSCA | Yes |
| 海關(guān)編號(hào) | 32041300 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| 上游原料 | 2-(4-氨基)-6-甲基苯并噻唑 |
| 參考資料 查看更多 | 1. 王瑞 朱文清 鄭潔 等. 原兒茶酸對(duì)人血清白蛋白淀粉樣纖維化的抑制作用[J]. 分析科學(xué)學(xué)報(bào) 2020 v.36(02):14-18.2. 郝徐藝, 羅思, 程淑意,等. 當(dāng)歸芍藥散對(duì)AD細(xì)胞模型銅離子介導(dǎo)的Aβ聚集的影響[J... |
硫黃素T，也被稱(chēng)為硫胺素T或維生素B1，是一種重要的維生素。
性質(zhì)：
硫黃素T是一種水溶性白色結(jié)晶性粉末，具有微弱的味。它是穩(wěn)定的，在光線、熱和酸性條件下相對(duì)穩(wěn)定。它在堿性環(huán)境下會(huì)迅速降解。
用途：
硫黃素T是一種必需的維生素，對(duì)維持人體正常的代謝功能至關(guān)重要。硫黃素T還被用于防治硫黃素T缺乏癥，該病在飲食中缺乏硫胺素T時(shí)會(huì)引發(fā)。
制法：
硫黃素T可以通過(guò)化學(xué)合成的方法制備。最常用的方法是以1-甘醇-3-酮為起始原料，經(jīng)過(guò)多步反應(yīng)制得硫黃素T。硫黃素T也可以通過(guò)天然來(lái)源，如酵母和谷類(lèi)中提取得到。
安全信息： 通常情況下，正常劑量的硫黃素T不會(huì)產(chǎn)生明顯的副作用。過(guò)量攝入硫黃素T可能導(dǎo)致胃腸道不適或過(guò)敏反應(yīng)。對(duì)于孕婦和有慢性疾病的人群，應(yīng)在醫(yī)師的指導(dǎo)下使用。